Corticosrone
皮质酮,又称 17-脱氧皮质醇和 11β,21-二羟基黄体酮,是一种 21 碳的皮质类固醇激素,在肾上腺皮质中产生。除了 17α-羟化酶缺乏导致的非常罕见的 先天性肾上腺增生症外,它对人类的重要性不大。在许多物种中,包括两栖 动物、爬行动物、啮齿动物和鸟类,皮质酮是一种主要的糖皮质激素,参与 调节能量、免疫反应和压力反应。皮质酮通过醛固酮合成酶转化为醛固酮, 醛固酮合成酶仅在肾小球细胞的线粒体中发现。肾小球细胞存在于肾小球区, 它是肾上腺皮质内分泌细胞的最表层区域。皮质酮是矿物皮质激素醛固酮的前体分子,是体内钠和钾水平的主要平衡调节剂之一。
可检测样本中大鼠的CORT,且与其类似物无明显交叉反应。
由于实验操作条件的不同( 如操作者、移液技术、洗板技术和稳定条件等),标准曲线的OD值会有所差异。以下数据和曲线仅供参考,实验者需根据自己的实验建立标准曲线。
板内变异系数小于10%,板间变异系数小于10%
在选取的健康大鼠血清、血浆和中加入3个不同浓度水平的大鼠CORT,计算回收率
分别在选取的4份健康大鼠血清、血浆和中加入高浓度大鼠CORT,在标准曲线动力学范围内进行稀释,评估线性。
注:ELISA试剂盒检测范围等数据,因检测样本 的不同而调整,实际数据以随货说明书为准。
Icariin ameliorates learning and memory impairments through ERK/CaMKIIα/CREB signaling and HPA axis in prenatally stressed female offspring
Rank: IF 6.9
Journal: Biomedicine & Pharmacotherapy
Year: 2019
DOI: 10.1016/j.biopha.2019.109077
Imperatorin ameliorates learning and memory deficits through BDNF/TrkB and ERK/CaMKIIα/CREB signaling in prenatally-stressed female offspring
Rank: IF 6.1
Journal: Phytotherapy Research
Year: 2020
DOI: 10.1002/ptr.6692
Ferulic Acid Improves Depressive-Like Behavior in Prenatally-Stressed Offspring Rats via Anti-Inflammatory Activity and HPA Axis
Rank: IF 4.9
Journal: International Journal of Molecular Sciences
DOI: 10.3390/ijms20030493
Tetrandrine inhibits aldosterone synthesis by covalently targeting CYP11A1 to attenuate hypertension
Rank: IF 4.4
Journal: Frontiers in Pharmacology
Year: 2024
DOI: 10.3389/fphar.2024.1387756
Effects of cannabidiol on AMPKα2 /HIF-1α/BNIP3/NIX signaling pathway in skeletal muscle injury
DOI: 10.3389/fphar.2024.1450513
Camellia nitidissima Chi extract promotes adult hippocampal neurogenesis and attenuates chronic corticosterone-induced depressive behaviours through regulating Akt/GSK3β/CREB signaling pathway
Rank: IF 3.8
Journal: Journal of Functional Foods
Year: 2022
DOI: 10.1016/j.jff.2022.105199
Beneficial effects of Dendrobium nobile Lindl. alkaloids (DNLA) on anxiety and depression induced by chronic unpredictable stress in rats.
Rank: IF 2.7
Journal: Brain Research
Year: 2021
DOI: 10.1016/j.brainres.2021.147647
Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis.
Journal: Brain Sciences
DOI: 10.3390/brainsci12050589
Electroacupuncture ameliorates cardiac dysfunction in myocardial ischemia model rats: a potential role of the hypothalamic-pituitary-adrenal axis
Rank: IF 2
Journal: Journal of Traditional Chinese Medicine
Year: 2023
DOI: 10.19852/j.cnki.jtcm.20230727.001
Seasonal photoperiodic influence of pineal melatonin on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in male rats
Rank: IF 0.7
Journal: Journal of Traditional Chinese Medical Sciences
DOI: 10.1016/j.jtcms.2022.03.005